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Anti–Programmed Cell Death (PD)-1 Immunotherapy for Malignant Tumor: A Systematic Review and Meta-Analysis  Ran Chen, Pei-Chun Peng, Bin Wen, Fu-Ying.

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Presentation on theme: "Anti–Programmed Cell Death (PD)-1 Immunotherapy for Malignant Tumor: A Systematic Review and Meta-Analysis  Ran Chen, Pei-Chun Peng, Bin Wen, Fu-Ying."— Presentation transcript:

1 Anti–Programmed Cell Death (PD)-1 Immunotherapy for Malignant Tumor: A Systematic Review and Meta-Analysis  Ran Chen, Pei-Chun Peng, Bin Wen, Fu-Ying Li, Sheng Xie, Guozhong Chen, Jiefu Lu, Zhuoyu Peng, Shao-Bo Tang, Yu-Mei Liang, Xin Deng  Translational Oncology  Volume 9, Issue 1, Pages (February 2016) DOI: /j.tranon Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Flowchart representing the systematic identification of studies. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Assessment of risk bias.
Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

4 Figure 3 Forest plot depicting the overall response rate of nivolumab compared with chemotherapy. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

5 Figure 4 Forest plot depicting the comparison of adverse events associated with nivolumab and chemotherapy. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

6 Figure 5 Forest plot depicting the 1-year OS rates of nivolumab and dacarbazine. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

7 Figure 6 Forest plot depicting the PFS rates associated with nivolumab and dacarbazine. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

8 Figure 7 Forest plot depicting the objective response rates associated with nivolumab and dacarbazine. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

9 Figure 8 Forest plot depicting the comparison of adverse events associated with nivolumab and dacarbazine. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

10 Figure 9 Forest plot depicting the overall response rate with different doses (2 and 10 mg/kg) of pembrolizumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

11 Figure 10 Forest plot depicting the PFS rates associated with different doses (2 and 10 mg/kg) of pembrolizumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

12 Figure 11 Forest plot depicting 1-year survival rates associated with different doses (2 and 10 mg/kg) of pembrolizumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

13 Figure 12 Forest plot depicting overall response rates of different doses (0.3 and 2 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

14 Figure 13 Forest plot depicting the PFS rates associated with different doses (0.3 and 2 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

15 Figure 14 Forest plot depicting the OS rates associated with different doses (0.3 and 2 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

16 Figure 15 Forest plot depicting the overall response rates associated with different doses (0.3 and 10 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

17 Figure 16 Forest plot depicting PFS rates associated with different doses (0.3 and 10 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

18 Figure 17 Forest plot depicting the OS rates associated with different doses (0.3 and 10 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

19 Figure 18 Forest plot depicting the overall response rates associated with different doses (2 and 10 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

20 Figure 19 Forest plot depicting the OS rates associated with different doses (2 and 10 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions

21 Figure 20 Forest plot depicting the PFS rates associated with different doses (2 and 10 mg/kg) of nivolumab. Translational Oncology 2016 9, 32-40DOI: ( /j.tranon ) Copyright © 2016 The Authors Terms and Conditions


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