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Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract.

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Presentation on theme: "Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract."— Presentation transcript:

1 Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain  Jeremy R. Johnson, MB ChB, Mary Burnell-Nugent, MB BChir, Dominique Lossignol, MB ChB, MRCG, DRCOG, Elena Doina Ganae- Motan, MD, Richard Potts, BSc (Hons), MICR, Marie T. Fallon, MB ChB, MD, FRCP (E), FRCP (Glasg)  Journal of Pain and Symptom Management  Volume 39, Issue 2, Pages (February 2010) DOI: /j.jpainsymman Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Fig. 1 Study design (Consolidated Standards of Reporting Trials [CONSORT] diagram). ITT=intent to treat. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

3 Fig. 2 Exposure to study medication—mean number of sprays per day. SE=standard error. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

4 Fig. 3 Pain 0–10 Numerical Rating Scale scores: responder analysis (ITT analysis). aOdds ratio (95% CI) THC:CBD vs. placebo; bFisher’s exact test. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions


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