1. Eviscerations

2. Why eviscerate? Scleral shell left behind –better cosmesis.
Indications: blind painful..painless / disfigured / not responding to treatment eye scenarios.
Comprise of blood frags, corneo-scleral disc, retina and uveal tissue, lens (lens prosthesis), vitreous.

4. What do you do with them? Examine all fragments. Bisect tissues
H&E, PAS, Perls +/- bug stains.
Are there histological hallmarks of sympathetic ophthalmia.
Any tumour?
Any pathology that can inform how the other eye will do?

6. Band keratopathy
Dystrophic calcification

7. Acute
inflammation

8. Chronic inflammation-chronic keratitis
Blood vessels
Plasma cells

9. Infective agent-bacteria

10. Endothelial
Cell
Loss

11. Host-donor interface
scar

14. New vessels on anterior stromal surface

15. Ectropion uveae, secondary to rubeosis

16. Fig 8.23 Rubeotic glaucoma

17. Grossly thickened basement membrane of pars plicata

18. Brown pigment clogging trabecular meshwork

28. Proliferative diabetic retinopathy Note new-vessels, surrounded
Fibrous tissue on retinal
surface.

30. Normal retinal arteriole

31. Arteriolosclerosis-note thick wall-called hyalinisation.
Hyalinisation due to accumulation of
lipid and fibrin, from
leaky vessel, due to pericyte death

32. Occluded branch venule. Note inflammation around vessel
-attempts at organisation
of thrombus

33. Perl’s stain picks up haemosiderin Stains it intense blue.
This indicates previous intra-retinal
haemorrhage from BRVO

35. Hard druse. Pink, homogeneous nodular material
Lies between RPE basement membrane and
inner collagenous part of Bruch’s.
Note overlying RPE arophy

36. Fluffier, more diffuse, soft drusen
Thickened Bruch’s
Fluffier, more diffuse, soft drusen

37. Thick Bruch’s, hard drusen and complete loss of photoreceptors

38. CNVM RPE RPE RETINA Haemorrhage of CNVM.
CNVM lies between neural retina
And RPE
Eventual organisation of haemorrhage
Will lead to disciform scar.
RPE
choroid
CNVM
RPE
RETINA

39. Vessel of CNVM
CNVM
choroid
RPE

41. Choriocapillaris intact
Granulomatous (non-caseating)
inflammation of uvea
(choroid in this case), sparing the
choriocapillaries

45. PRP SCAR

46. Loss of choriocapillaris Loss of RPE Bruch’s
Gliotic retina
PRP SCAR-loss of RPE and choriocapillaris
Retinochoroidal atrophy
Retinal gliosis
Gliotic retina in direct apposition to Bruch’s