1. Cell Electrophysiology Simulation Environment (CESE)
29 June, 2006

2. CESE Computational electrophysiological simulations action potentials
individual ionic currents
changes in ionic concentrations
Cross-platform (JRE 1.4 or above)
Windows, Linux, Solaris, MacOS X, AIX

3. Users Single-cell model Electrical activity Future neuronal model
Hodgkin-Huxley
Markovian current formulations
Electrical activity
Future neuronal model

4. Features Uniform interface Voltage clamp for complex model behavior
Data visualization
Current-voltage plots and statistical parameter calculation
Export to ASCII, ATF, NetCDF
CellML

5. Developers Java API Implementation of house-keeping routines
Models conform to JavaBeans specification
XML clamping commands
Java object serialization
Open-source

6. Model Creation What you need: Extending model Creating model
J2SDK
Java IDE
CESE source
Extending model
Creating model
Data exporter

7. Example Luo-Rudy Mammalian Ventricular Model I, 1991
Simulate guinea pig ventricular action potentials

8. Hodgkin-Huxley Equation

9. Extending Model Replacement Object oriented programming
modify source code
change BeanInfo class
recompile package
Object oriented programming
extend class
Override BeanInfo class
recompile

10. Create New Model Override doSimulate() method JavaBeans specification
Private
Read-only

11. Export Data public abstract void prepareExport()
public abstract void doExport(int count)
public abstract void finishExport()

12. Is It Useful? Fancy plotter
Any model that is similar to that in our case?
Simple stepper
Limited functions
Hodgkin-Huxley and Markovian can be “mixed”
Only one Markovian current formulations