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Reversing Neurodegeneration:A Promise Unfolds

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Presentation on theme: "Reversing Neurodegeneration:A Promise Unfolds"— Presentation transcript:

1 Reversing Neurodegeneration:A Promise Unfolds
Harry T Orr, Huda Y Zoghbi  Cell  Volume 101, Issue 1, Pages 1-4 (March 2000) DOI: /S (00) Copyright © 2000 Cell Press Terms and Conditions

2 Figure 1 A Model of Polyglutamine-Induced Neurodegeneration and Its Reversal (A) Expression of a mutant peptide with expanded polyglutamine (Q) tract leads to neuronal degeneration and eventual death. Note that both aggregated and solitary protein induce neuronal dysfunction that precedes death. (B) Turning off mutant protein expression gives the neuron enough of a reprieve to clear the mutant protein by the chaperone/ubiquitin-proteasome pathway (UPP) and subsequently recover at least some function. Cell  , 1-4DOI: ( /S (00) ) Copyright © 2000 Cell Press Terms and Conditions

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