1. IFN-Lambda: The Key to Norovirus’s Secret Hideaway
Sonja M. Best, Shelly J. Robertson 
Cell Host & Microbe 
Volume 22, Issue 4, Pages (October 2017)
DOI: /j.chom
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2. Figure 1 The Role of IFN-λ Antagonism in Norovirus Persistence
Left panel: acute NoV infection does not result in infection of intestinal epithelial cells (IECs) due to induction of host IFN-λ signaling that cannot be antagonized by the virus. In this case, infection of alternative cell types such as macrophages, dendritic cells, and B cells results in efficient antigen presentation, proliferation of virus-specific tissue-resident memory CD8 T (Trm) cells, and virus clearance. Right panel: persistent NoV infection is associated with efficient antagonism of IFN-λ signaling specifically in IECs. Infection of IECs creates an immunologically privileged site and may result in failure of antigen availability for proliferation of Trm cells, thus facilitating prolonged virus shedding.
Cell Host & Microbe  , DOI: ( /j.chom )
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