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Macrophages’ Choice: Take It In or Keep It Out

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Presentation on theme: "Macrophages’ Choice: Take It In or Keep It Out"— Presentation transcript:

1 Macrophages’ Choice: Take It In or Keep It Out
Carl Nathan  Immunity  Volume 45, Issue 4, Pages (October 2016) DOI: /j.immuni Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Macrophages that Encounter Bacteria or Other Foreign Objects Have a Choice: Take Them In or Keep Them Out Plan A: a macrophage ingests a bacterium, kills it, and digests it. Plan B: the macrophage fails to kill the bacterium, which replicates, or fails to digest other types of foreign objects, which persist. Other macrophages arrive and help to form a granuloma. They express E-cadherin (indicated by the brown band) and establish tight junctions (symbolized by the paired bars) with each other, forming a pseudoepithelium that positions the bacteria or foreign objects as if they lay outside the skin of the host. Immunity  , DOI: ( /j.immuni ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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