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The Yop virulon of Yersinia: a bacterial weapon to kill host cells

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1 The Yop virulon of Yersinia: a bacterial weapon to kill host cells
Isabelle Stainier, Guy R. Cornelis  Clinical Microbiology and Infection  Volume 4, Issue 12, Pages (December 1998) DOI: /j tb00650.x Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

2 Figure 1 Yersinia facing a eukaryotic cell. At 37°C in a rich environment, the Ysc secretion machinery is assembled in the bacterial membranes and Yop proteins are synthesized. Some of them are covered by their specific Syc chaperones. Upon contact with a eukaryotic cell, the YopN–TyeA–LcrG plug is removed, opening the secretion channel. The YopB translocator is inserted in the eukaryotic cell membrane with the help of YopD and LcrV. The various Yop effectors are then translocated across the plasma membrane in order to disarm the eukaryotic cell. Clinical Microbiology and Infection 1998 4, DOI: ( /j tb00650.x) Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions


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