Download presentation
Presentation is loading. Please wait.
1
Abnormalities in the serum insulin-like growth factor-1 axis in women with hyperandrogenism
Héctor F Escobar-Morreale, M.D., Ph.D., Joaquı́n Serrano-Gotarredona, M.D., Rafael Garcı́a-Robles, M.D., Ph.D., César Varela, M.D., Ph.D., José M Sancho, M.D., Ph.D. Fertility and Sterility Volume 70, Issue 6, Pages (December 1998) DOI: /S (98)
2
FIGURE 1 Comparison of the serum IGF-1, IGFBP-3, GH, and insulin concentrations, and of the glucose/insulin ratio, of the different patient groups with those of the control group. Values are means ± SEM. IH = idiopathic hirsutism; FOH = functional ovarian hyperandrogenism; FAH = functional adrenal hyperandrogenism. ∗P <.001 vs. the control, IH, and FOH groups, by one-way ANOVA and the least significant difference test. †At least P <.05 vs. the control group, by one-way ANOVA and the least significant difference test. Fertility and Sterility , DOI: ( /S (98) )
3
FIGURE 2 Comparison of the activity of adrenal enzymes of the patient groups with those of the control group. Values are means ± SEM. The molar ratios of the increments in serum steroid levels in response to ACTH stimulation signify the following adrenal enzyme activities: overall P450c17α (A) = ΔA/ΔP ratio; 17-hydroxylase (B) = Δ17-OHP/ΔP ratio; 17,20-lyase (C and D) = ΔA/Δ17-OHP and ΔA/ΔF ratio; 21α-hydroxylase (E) = Δ17-OHP/ΔF; and 11β-hydroxylase (F) = ΔS/ΔF. IH = idiopathic hirsutism; FOH = functional ovarian hyperandrogenism; FAH = functional adrenal hyperandrogenism; 17-OHP = 17α-hydroxyprogesterone; P = progesterone. ∗At least P <.05 vs. the control group by one-way ANOVA and the least significant difference test. Fertility and Sterility , DOI: ( /S (98) )
4
FIGURE 3 Comparison of the activity of ovarian enzymes among the groups of hirsute patients. Values are means ± SEM. The molar ratios of the increments between baseline and day 1 in serum steroid levels in response to triptorelin signify the following ovarian activities: overall P450c17α (top) = ΔA/ΔP ratio; 17-hydroxylase (middle) = Δ17-OHP/ΔP ratio; and 17,20-lyase (bottom) = ΔA/Δ17-OHP. IH = idiopathic hirsutism; FOH = functional ovarian hyperandrogenism; FAH = functional adrenal hyperandrogenism; 17-OHP = 17α-hydroxyprogesterone; P = progesterone. ∗At least P <.05 vs. the IH and FOH groups by one-way ANOVA and the least significant difference test. Fertility and Sterility , DOI: ( /S (98) )
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.