1. Innate Immunity

6. Other surface protections against pathogen entry:
Microbial Antagonism
Microbially-produced acids
Bacteriocins

7. Major cellular player: Macrophages & Neutrophils

9. Inflammation:
Bring killing-cells to site of infection
Block spread of infectious agent
Repair injured tissue

10. Receptors that help immune system cells recognize pathogens:
Non-specific recognition of microbial substances initiates an innate immune response, release of cytokines and chemokines.
Receptor/substrate interaction

11. Mannose-binding lectin (MBL)- pattern recognition receptor

12. Toll-like Receptors (TLR)

13. TLRs trigger:
cytokines
chemokines
Cell surface molecules necessary for adaptive immune responses

14. Complement: a set of blood proteins that, once activated, lead to…

15. View textbook CD movie 9.2

16. Classical Pathway activation: Ab binds to microbe surface
MB-Lectin Pathway activation: MBL binds to sugars on microbe surface
Alternative Pathway activation: Spontaneous cleavage of C3
cascade continues on pathogen surface
cascade is inhibited on human cell surface