1. Collaboration is required for successful immunotherapy
by Soldano Ferrone, and Eric Ko
Blood
Volume 107(8):
April 15, 2006
©2006 by American Society of Hematology

2. Enhanced tumor antigen–specific CTL response is generated by cross talk between NK cells, DCs, and CD8+ T cells and reduction in CD4+CD25+ T regulatory (Treg) cell numbers at the priming site.
Enhanced tumor antigen–specific CTL response is generated by cross talk between NK cells, DCs, and CD8+ T cells and reduction in CD4+CD25+ T regulatory (Treg) cell numbers at the priming site. Immunization strategies that trigger the innate and adaptive arms of the immune system and reduce the number of Treg cells generate a more effective tumor antigen–specific CTL response (left panel) than those that trigger only the adaptive arm of the immune system (right panel).
Soldano Ferrone, and Eric Ko Blood 2006;107:
©2006 by American Society of Hematology