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Effective Management of Psoriatic Arthritis: Tailoring Treatments

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Presentation on theme: "Effective Management of Psoriatic Arthritis: Tailoring Treatments"— Presentation transcript:

1 Effective Management of Psoriatic Arthritis: Tailoring Treatments

2 Psoriatic Arthritis Clinical Manifestations

3 Psoriatic Arthritis Clinical Manifestations (cont)

4 Psoriatic Arthritis Clinical Manifestations (cont)

5 Psoriatic Arthritis Comorbidities

6 Psoriatic Arthritis Contributing Factors to Psoriasis

7 Key Cells and Mediators: Transition From Innate to Adaptive Immunity

8 Pathogenesis of Psoriatic Arthritis

9 Treatment of Psoriatic Arthritis

10 Newer Treatment Options

11 Emerging Treatments for Psoriatic Arthritis

12 Treatment of Psoriatic Arthritis The Pathophysiologic Cascade

13 Cytokine Signaling Pathways cAMP/PKA

14 Ustekinumab Inhibits p40 Moiety

15 IL-17 Inhibitors

16 Cytokine Signaling Pathways JAK

17 Mechanism of Action of Abatacept

18 Guselkumab: IL-23, p19

19 New Domain Core Set for Psoriatic Arthritis

20 Core Domains to Evaluate in Clinical Trials

21 GRAPPA 2015 Treatment Recommendations

22 GRAPPA 2015 Treatment Recommendations: Peripheral Arthritis

23 GRAPPA 2015 Treatment Recommendations: Axial Disease

24 GRAPPA 2015 Treatment Recommendations: Enthesitis and Dactylitis

25 GRAPPA 2015 Treatment Recommendations: Skin and Nails

26 Case: Aggressive Disease 55-Year-Old Man

27 Joint Examination

28 Choosing a Therapy

29 GRAPPA Minimal Disease Activity Criteria

30 Case: Disease Progression 40-Year-Old Woman

31 Evaluation for Inflammatory Back Pain

32 Treatment and Management

33 Concluding Remarks

34 Abbreviations

35 Abbreviations (cont)

36 Abbreviations (cont)

37 Abbreviations (cont)


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