1. 2016 Prioritized Research Gaps – PTSD
Conduct head-to-head comparative effectiveness trials for PTSD that include better controls
Conduct well-controlled trials to examine integrated approaches to care for PTSD patients with multi-morbidity and psychosocial complexities
Examine the efficacy or effectiveness of combined treatment components for PTSD
Determine how sex and racial differences impact on prevalence of PTSD and impact on treatment
Examine efficacy of novel pharmacotherapies for PTSD based on emerging basic science
Conduct research to evaluate the effectiveness of widely-used PTSD treatment programs with inconsistent or limited evidence
Improve understanding of possible PTSD biomarkers, taking into account limitations in specificity, or predisposing or environmental factors such as early childhood trauma
Conduct research to improve implementation, delivery, and reach of tele- and mobile health interventions for PTSD in the AD population
Conduct well controlled trials for mindfulness based approaches for PTSD
Conduct well controlled trials on non-standard psychological treatments for PTSD

2. 2016 Prioritized Research Gaps – Depression
Conduct head-to-head comparative effectiveness trials for depression that include better controls
Determine how sex and racial differences impact prevalence of depression and impact on treatment
Conduct research to evaluate the effectiveness of widely-used depression treatment programs with inconsistent or limited evidence
Conduct research to examine the best approach for delivering repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression in the military
Conduct research to improve implementation, delivery, and reach of tele- and mobile health interventions for depression in the AD population
Examine benefits and weaknesses of interventions for depression with a limited evidence base being used in the health care system