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Improved outcome in central nervous system aspergillosis, using voriconazole treatment by Stefan Schwartz, Markus Ruhnke, Patricia Ribaud, Lawrence Corey,

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Presentation on theme: "Improved outcome in central nervous system aspergillosis, using voriconazole treatment by Stefan Schwartz, Markus Ruhnke, Patricia Ribaud, Lawrence Corey,"— Presentation transcript:

1 Improved outcome in central nervous system aspergillosis, using voriconazole treatment
by Stefan Schwartz, Markus Ruhnke, Patricia Ribaud, Lawrence Corey, Timothy Driscoll, Oliver A. Cornely, Ulrich Schuler, Irja Lutsar, Peter Troke, and Eckhard Thiel Blood Volume 106(8): October 15, 2005 ©2005 by American Society of Hematology

2 Serial neuroradiologic studies in a patient with CNS aspergillosis.
Serial neuroradiologic studies in a patient with CNS aspergillosis. Coronal MRI scans showing complete resolution of a single brain abscess after 133 days of voriconazole therapy. (A) Prior to start of voriconazole. (B) After therapy. Stefan Schwartz et al. Blood 2005;106: ©2005 by American Society of Hematology

3 Kaplan-Meier survival curve of patients with CNS aspergillosis.
Kaplan-Meier survival curve of patients with CNS aspergillosis. Survival curve of 81 patients with primary/salvage voriconazole therapy. Stefan Schwartz et al. Blood 2005;106: ©2005 by American Society of Hematology

4 Kaplan-Meier survival curves of patients with CNS aspergillosis according to application of neurosurgical interventions. Kaplan-Meier survival curves of patients with CNS aspergillosis according to application of neurosurgical interventions. Survival curves comparing voriconazole-treated patients who had neurosurgery (n = 31) versus those with no or unknown neurosurgery (n = 50). Stefan Schwartz et al. Blood 2005;106: ©2005 by American Society of Hematology


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