1. Antimicrobial Resistance: Plans for Korea and Beyond
27th Management Board Meeting
Joint Programming Initiative on Antimicrobial Resistance
Antimicrobial Resistance:
Plans for Korea and Beyond
Jaesang Kim
Kyeong Kyu Kim
Director, Next Generation Biotechnology
National Research Foundation of Korea
Ministry of Science and ICT
Professor & Director
Institute for Antimicrobial Resistance Research & Therapeutics
Sungkyunkwan University, Korea

2. National Research Foundation of Korea
Partner to Ministry of Science and ICT
Supporting research efforts in Science and Technology
With an annual budget near 4 billion EURO

3. Bio & Medical Technology Development Program
Goal
Aims to acquire core fundamental technologies in the field of biomedical engineering and to develop strategies for application in actual healthcare
2017
Budget 2017
Total Budget in 2017:
263 billion KWon
200 million EURO

4. NRF and JPIAMR, a brief history
National Action plan on Antimicrobial Resistance (Aug. 2016)
Adoption of AMR as priority issue by NRF (Jan. 2017)
Adoption of AMR as international cooperation topic (Jan. 2017)
Exploration during General Assembly of Glopid-R (Mar. 2017)
New R&D projects launched (Aug. 2017)
NRF presentation at the 6th KOR-EU S&T Cooperation Committee Meeting (Sep. 2017)
Letter of Interest in joining JPIAMR (Jan. 2018)
27th Management Board Meeting (Feb. 26, 2018)

5. The Current Situation in Korea
A very high DDD of 31.7 in 2014
MRSA very common (> 60% of S. aureus)
A very high ratio of Vancomycin-resistant E. faecium
Resistance to fluoroquinolone extremely high among chicken enterococci (79.7%; Denmark 6%)
Resistance to Sulpha drugs extremely high among chicken enterococci (9.1%; Denmark 2%)
year
Major H
2nd tier H
Local H
Conval H
2007(%)
26.0
15.5
5.0
20.5
2014(%)
36.5
22.1
24.7
49.1

6. How we began to fight back

7. Multi-agency effort for One Health
Korean Centers for Disease Control and Prevention; Health Insurance Review and Assessment; Ministry of Health and Welfare; Ministry for Food, Agriculture, Forestry and Fisheries; Ministry of Oceans and Fisheries; Ministry of Food and Drugs Safety; Ministry of Science and ICT; Ministry of Strategy and Finance; Ministry of Interior; Ministry of Foreign Affairs
Promote the prudent use of antimicrobial medicines
Prevent the spread of antimicrobial resistance
Strengthen the surveillance system
Improve public awareness
Strengthen research and development
Enhance international collaboration

8. Role of NRF and Ministry of Science and ICT
A new R&D fund for fighting AMR
Coordinating role in government-wide R&D planning, evaluation and budgeting for AMR
Focus on basic research of AMR
- Understanding pathogenic mechanisms
- Identification of novel targets
- Development of novel strategy and reagents
Global networking and collaboration for AMR
- Sharing the knowledge and experience
- Increased awareness of AMR
- Improved policy making and implementing
- Efficient research and development

9. Sungkyunkwan University, Korea (IAMRT-SKKU, Korea)
Institute for AMR Research and Therapeutics
Sungkyunkwan University, Korea
(IAMRT-SKKU, Korea)
GLOPID-R
WHO
International AMR research groups
JPIAMR
International AMR Research Network
National AMR Research Network
ESKAPE(E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter spp., Pseudomonas aeruginosa, Enterococcus spp.)
JPIAMR Joint Programming Initiative on Antimicrobial Resistance
Korean Centers for Disease Control and Prevention
Research on Multi-drug Resistant Bacteria
Mechanism-Based Approach
Agent-based Approach
Korea Health Industry Development Institute
Research on Multi-drug Resistant Bacteria
Korea National Institute of Health
National Research Foundation
(Ministry of Science and ICT, Korea)
Ministry of Health and Welfare

10. IAMRT-SKKU, Korea Goal Mission Plan
The institute aims to understand the principle of antibiotic resistance and to develop novel antimicrobial therapeutics.
Mission
Conveying breakthrough research on AMR and providing a practical solution to AMR in conjunction with international communities working on AMR.
Bringing in all relevant research activities carried out by various ministries and agencies in Korea under one umbrella leading to coordination not just within Korea but also with the rest of the world.
Plan
Hosting an international workshop or conference on AMR research.
Building a national AMR research network in Korea.
Participating in JPIARM activities as a regular member country.
Connecting Korean AMR researchers with JPIAMR for the international collaboration.
Initiating the international collaboration and idea exchange in Asia (propose)
ESKAPE(E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter spp., Pseudomonas aeruginosa, Enterococcus spp.)
JPIAMR Joint Programming Initiative on Antimicrobial Resistance

11. Research projects supported by NRF
Mechanism-based approaches
Targeting the master virulence regulating signals for controlling multidrug resistant bacteria.
Identification of novel virulence and resistance factors from the clinically isolated drug-resistance pathogens by applying the multiplex approaches.
Anti-superberg strategy targeting the key functionalities and components of the bacterial cell membrane.
Agent-based approaches
Structure-based development of inhibitors targeting the class B carbapenemase.
Development of peptide and peptido-mimetic potentiators for repositioning drugs against drug-resistant bacteria
ESKAPE(E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter spp., Pseudomonas aeruginosa, Enterococcus spp.)
JPIAMR Joint Programming Initiative on Antimicrobial Resistance