1. Volume 152, Issue 5, Pages 941-943 (April 2017)
Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator 
Jean-Charles Nault 
Gastroenterology 
Volume 152, Issue 5, Pages (April 2017)
DOI: /j.gastro
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2. Figure 1
Role of the MAPK pathway in liver carcinogenesis. The authors performed genome-wide CRISPR/CAS 9 screening in liver progenitor cells subcutaneously implanted in nude mice. Genetic analysis of the tumor and subsequent in vivo and in vitro experiments validated the role of neurofibromatosis type 1 (NF1) as a tumor suppressor gene, and the RAS/RAF/MAPK pathway as a key signaling pathway in hepatocellular carcinoma (HCC) development. Percentages of mutations in human HCC are shown in blue for tumor suppressor genes and red for oncogenes; potential biotherapy is shown in purple.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2017 AGA Institute Terms and Conditions