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Margaretha A. Faber, MD, Vito Sabato, MD, Chris H

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Presentation on theme: "Margaretha A. Faber, MD, Vito Sabato, MD, Chris H"— Presentation transcript:

1 Clinical relevance of the Hevea brasiliensis lipid transfer protein Hev b 12 
Margaretha A. Faber, MD, Vito Sabato, MD, Chris H. Bridts, MT, Ajay Nayak, PhD, Donald H. Beezhold, PhD, Didier G. Ebo, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 135, Issue 6, Pages e1 (June 2015) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Basophil activation with rHev b 12. Percentages of CD63+ and CD203c++ basophils after stimulation with 5 different concentrations of rHev b 12 in patients with latex allergy and Hev b 12 sensitization (n = 2, red line), patients with latex allergy without Hev b 12 sensitization (n = 3, green line), and 3 healthy control subjects (black line). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Basophil selection and activation: BAT plot in a patient with latex allergy and sensitization to rHev b 12 and nCan s 3. A and B, Detection of basophils by using side scatter (SSC) and gating out IgEhigh and CD203c+ cells. C, Within this gate, numbers of activated basophils expressing CD63 were measured. Stimulation with activation buffer served as a negative control for spontaneous CD63 expression. D, Stimulation with anti-human IgE (10 μg/mL, BD Biosciences) was used as a positive control. E-H, Basophil stimulation with NRL extract (1 μg/mL), rHev b 12 (0.1 μg/mL), nCan s 3 (0.1 μg/mL), and nPru p 3 (0.1 μg/mL), respectively. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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