1. Interaction of local anaesthetics with recombinant μ, κ, and δ-opioid receptors expressed in Chinese hamster ovary cells 
K. Hirota, H. Okawa, B.L. Appadu, D.K. Grandy, D.G. Lambert 
British Journal of Anaesthesia 
Volume 85, Issue 5, Pages (November 2000)
DOI: /bja/
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
(a) Lidocaine concentration-dependently displaced [3H]DPN from CHO-κ, μ and δ with the following rank order: κ > μ > δ. (b) Interaction of a range of local anaesthetics with μ-opioid receptor. Concentration– response curves are corrected for the competing mass of [3H]DPN according to Cheng and Prusoff.23 All data are mean (SEM) (n=5).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Interaction of bupivacaine isomers with μ- (a), κ- (b) and δ (c)-opioid receptors. All data are mean (sem) (n=5). For CHO-μ and -κ, there is a suggestion of stereoselectivity (i.e. the curve for S(–)bupivacaine tends to the right).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
(a) Lidocaine produced a concentration-dependent inhibition of forskolin-stimulated cAMP formation in CHO cells expressing μ, κ, δ opioid receptors (CHO-μ, κ, δ) and in untransfected wt cells. (b) Lidocaine-induced inhibition of forskolin-stimulated cAMP formation was naloxone insensitive. All data are mean (SEM) (n=4–5).
British Journal of Anaesthesia  , DOI: ( /bja/ )
Copyright © 2000 British Journal of Anaesthesia Terms and Conditions