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Does Reduced Creatine Synthesis Protect against Statin Myopathy?

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Presentation on theme: "Does Reduced Creatine Synthesis Protect against Statin Myopathy?"— Presentation transcript:

1 Does Reduced Creatine Synthesis Protect against Statin Myopathy?
Kevin D. Ballard, Paul D. Thompson  Cell Metabolism  Volume 18, Issue 6, Pages (December 2013) DOI: /j.cmet Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Proposed Mechanism by which Reduced GATM Activity Reduces Statin Myopathy Risk Simvastatin reduced GATM transcriptional expression, and this effect was associated with a reduced incidence of statin myopathy (Mangravite et al., 2013). Reduced intramuscular Cr may protect against statin-induced myopathy. GATM, glycine amidinotransferase; CP, creatine phosphate; Cr, creatine. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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