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Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation  Lena Rivard, MD, MSc, Paul Khairy, MD,

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Presentation on theme: "Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation  Lena Rivard, MD, MSc, Paul Khairy, MD,"— Presentation transcript:

1 Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation  Lena Rivard, MD, MSc, Paul Khairy, MD, PhD  Canadian Journal of Cardiology  Volume 33, Issue 12, Pages (December 2017) DOI: /j.cjca Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

2 Figure 1 Summary of meta-analyses on AF and cognitive impairment. Three meta-analyses have assessed the association between AF and cognitive impairment. The diamonds represent point estimates from pooled analyses for each meta-analysis. AF, atrial fibrillation; CI, confidence interval; HR, hazard ratio; OR, odds ratio; RR, relative risk. Canadian Journal of Cardiology  , DOI: ( /j.cjca ) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

3 Figure 2 Silent cerebral ischemia. Shown are cerebral magnetic resonance imaging transverse axial views of the brain in a 59-year-old man with paroxysmal atrial fibrillation, a Congestive Heart Failure, Hypertension, Age (≥75 years), Diabetes, Stroke/Transient Ischemic Attack, Vascular Disease, Age (65-74 years), Sex (Female) (CHA2DS2-VASc) score of 0, and mild cognitive impairment. The white spots in the cerebral cortex represent multiple areas of silent cerebral ischemia. Canadian Journal of Cardiology  , DOI: ( /j.cjca ) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

4 Figure 3 Overview of proposed pathophysiological mechanisms linking atrial fibrillation to cognitive impairment and therapeutic modalities investigated. Canadian Journal of Cardiology  , DOI: ( /j.cjca ) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

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