1. Proteins: Tertiary structure
CHMI 2227E Biochemistry I
Proteins:
Tertiary structure
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2. Tertiary structure
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3. Tertiary structure
Collagen
myoglobin
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4. Tertiary structure Interaction forces
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5. Tertiary structure A B
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6. Tertiary structure Folding motifs - 1
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7. Tertiary structure Folding motifs - 2
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8. Tertiary structure Protein domains – Pyruvate kinase
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9. Tertiary structure 1. Myoglobin
b-turn
Proline
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10. Tertiary structure 1. Myoglobin
Cross-sectional view
Hydrophilic amino acids: Blue
Hydrophobic amino acids: Yellow
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11. Tertiary structure 2. Porin – a membrane-bound protein
Hydrophilic amino acids: Blue
Hydrophobic amino acids: Yellow
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12. Tertiary structure Chaperones
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13. Tertiary structure Protein denaturation
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14. Tertiary structure Protein denaturation
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15. Examples of proteins 1. Green fluorescent protein
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16. Examples of proteins 1. Green fluorescent protein
Light!
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17. Examples of proteins 1. Green fluorescent protein
Golgi apparatus
Nucleus
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18. Examples of proteins 1. Green fluorescent protein
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19. Examples of proteins 2. Prion proteins
Normal form = PrPc
Toxic form = PrPsc
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20. Examples of proteins 2. Prion proteins
Fiber aggregation
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21. Important web site: http://www.pdb.org/pdb/home/home.do
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