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Biomarker-Driven Management of Sepsis and Antibiotics Evidence and Perspectives.

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Presentation on theme: "Biomarker-Driven Management of Sepsis and Antibiotics Evidence and Perspectives."— Presentation transcript:

1 Biomarker-Driven Management of Sepsis and Antibiotics Evidence and Perspectives

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3 Sepsis and Septic Shock

4 Current Challenges in Sepsis

5 Biomarkers in Sepsis

6 Diagnostic Criteria for Sepsis

7 Challenges in Diagnosing Sepsis

8 Lactate

9 Elevated Lactate Predicts Mortality

10 Cytokines

11 Cytokine Concentrations at Presentation to the ED

12 C-Reactive Protein

13 Procalcitonin

14 PCT Kinetics Provide Important Information on Prognosis of Sepsis Patients

15 Diagnostic Accuracy of PCT Compared With Other Biomarkers Used In Sepsis

16 Adding PCT Results to Clinical Assessment Improves Accuracy of Early Clinical Diagnosis of Sepsis

17 Mortality and PCT Kinetics Over 72 Hours

18 Role of Nurses in Sepsis Care

19 Patient Case Examples

20 Sepsis Protocol Implementation

21 Sepsis Protocol Implementation (cont)

22 Sepsis Protocol Implementation (cont)

23 Goals of Antibiotic Stewardship Programs

24 2016 Guidelines for Implementing an ASP

25 Patient Case

26 Patient Case 2 Hours Later

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