1. PREVALENCE OF HIGH RISK FOR TYPE2 DIABETES IN CENTRAL SPAIN
11th Meeting of the Mediterranean Group for the Study of Diabetes
Malta, April 23-26, 2009
Rafael Gabriel
Hospital Universitario la Paz, Madrid

2. Prof. Jaakko Tuomilehto
DIABETES IN EUROPE: PREVENTION USING LIFESTYLE,
PHYSICAL ACTIVITY AND NUTRITIONAL INTERVENTION (DE-PLAN)
EUROPEAN Project :
25 centers, 17 countries
Prof. Jaakko Tuomilehto

3. DE-PLAN STUDY CENTRAL-SPAIN
(Screening Phase; n=3.007)
Burgos
Avila
Madrid
Toledo
MADRID:
COORDINATING CENTER
CENTRAL LAB.

4. DE-PLAN PRIMARY OBJECTIVES:
To detect high risk individuals for T2D in the general adult population (screening phase)
Feasibility & effectiveness of lifestyle interventions (diet & physical activity) for primary prevention of T2D in high risk individuals (intervention phase)

5. DE-PLAN STUDY DESIGN

6. FINDRISC
8 questions about: age, BMI, waist, physical activity, diet, hypertension, history of high glucose values, family history of diabetes
Predicted 10-year diabetes risk with 78% sensitivity and 77% specificity
Lindström et al.
Diabetes Care 2003;26:

7. DE-PLAN CENTRAL-SPAIN
Study population:
(n=3.007; years):
Two random samples:
1.026 subjects from the general population of Madrid
1.981 subjects from Primary Care registries

8. HIGH RISK FOR T2D (FINDRISC >14) IN SUBJECTS 45-70 YEARS IN SPAIN
MALES
24.7%
16.7%
FEMALES
33.6%
19.8%
ALL
28.6%
18.4%
Primary Care
(n=1.981)
General population
(n=1.026)

9. HIGH-RISK OF T2D BY AGE, SEX AND SETTING
General pop.
Primary Care

10. HIGH-RISK OF T2D BY BMI
General pop.
Primary Care

11. WAIST AND HIGH-RISK OF T2D
General pop.
Primary Care

12. OGTT IN THE GENERAL POPULATION
Population-based
random sample
Diabetes (FBG & Rx)
210
n: 2000
OGTT
FINDRISK POSITIVE
N: 800
FINDRISK NEGATIVE N:
IGT: 80
IFBG: 390
NGT: 190
DIAB: 140
IGT: 100
IFBG: 160
NGT: 920
DIAB: 20
Known Diabetes: 210/2210 = 9.5%
Unknown Diabetes: 160/2000 = 8.0%
Impaired Glucose Tolerance:180/2000= 8.1%

13. OGTT IN PRIMARY CARE
(OGTT in high risk subjects)
100%
16%
19%
48%
17%