1. Cytosolic DNA Sensing: The Field Narrows
Russell E. Vance 
Immunity 
Volume 45, Issue 2, Pages (August 2016)
DOI: /j.immuni
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
A Narrowing Field of Cytosolic DNA Sensors Triggering IFN Production
Genetic data now point to cyclic-GMP-AMP synthase (cGAS) as the only viable IFN-inducing DNA sensor, depicted in this illustration as the last man standing. It remains unclear whether other putative cytosolic DNA sensors, previously proposed to induce type I IFN expression in response to dsDNA, are truly dead and buried or whether these proteins will have roles in response to specific stimuli in certain cellular contexts.
Immunity  , DOI: ( /j.immuni )
Copyright © 2016 Elsevier Inc. Terms and Conditions