1. Leukemia
Human Disease Asma Siddique BIOT 412

2. What is Leukemia?
Cancer of blood Blood cells formed in bone marrow Affects the ability to produce normal cells

4. Types of Leukemia
ChronicLymphpcytes Leukemia (CLL)Acute Lymphocytes leukemia(ALL)Chronic Myelogenous Leukemia(CML)Acute myelogenous Leikemia(AML)

6. Cytogenetic and Molecular Biology of CML
Genetic abnormality- associaed with Philadephia chromosomeTranslo cation betweenchromosom e no. 9 and 22.

7. Cytogenetic and molecular biology of CML
Ph chromosome translocation splices genetic segments in abnormal hybrideHybride BCR – ABL gene encode fully activated BCR-ABL fusion protein-derives leukemia transfusion

8. Symtoms
Fever, night sweatsWeakness, fatigue, headacheWeight lossTender and swollen lymph nodesSwollen liverSwollen and bleeding gumsBreathing difficulties

9. Test for diagnosis
Physical examine – such as enlarged spleenCBC Cytogenetic Analysis – to check changes in chromosomesBone marrow aspiration / biopsy

11. Treatment
ChemotherapyImmunotherapyRadiation TherapyBone Marrow Transplant

12. Who is at Risk?
Radiation exposure- high level radiation- low level radiationChemicalsRace / Gender

13. Research
New drugsCord blood ; placentaConclusion