1. AHA Northwestern Strategically-Focused Children’s Research Center
Early Life Origins of Cardiovascular Health: Healthier, Earlier
A DevSci Healthier, Earlier Translational Partnership
INTEGRATED INTERDISCIPLINARY COLLABORATIONS
AHA SFRN NORTHWESTERN CENTER AIMS:
Blend expertise in pediatric cardiology & neurodevelopment (PI Marino), and cardiovascular epidemiology & preventive medicine (Co-PI: Lloyd–Jones) to:
Reduce burden of CVD by altering its developmental origins
Establish a novel paradigm for measuring, monitoring, and modifying CVH trajectories in early life
Assess the modifying effects of early life neurodevelopmental health and children's social environment on CVH trajectories
Foster the next generation of translational scientists in CVH and neurodevelopment
BUILDING AN EVIDENCE BASE FOR PROMOTING CVH HEALTH FROM BIRTH
UNIFYING OBJECTIVE: CLOSE THE 0-8 GAP TO ENABLE
PROMOTION OF CVH BEGINNING AT BIRTH
CROSS-CUTTING OBJECTIVE: DISCOVER HOW EARLY NEURODEVELOPMENTAL HEALTH MODIFIES EMERGENT CVH
POPULATION SCIENCE
CVH Trajectories: Birth to Adolescence
PI: Nori Allen, PhD, MPH
Cardiovascular Epidemiologist, DPM/FSM
Use big data methods to model developmental trajectories of CVH risk from 0-12 yrs.
CLINICAL SCIENCE
Keeping IDeal CVH
Family Intervention Trial (KIDFIT):
PI: Linda Van Horn, PhD, RD
Nutrition Science, DMP/FSM
Test the efficacy of a family based preschool obesity prevention a high risk sample
Brad Marino, MD, MPP, MSCE, FAHA
Pediatrician, PEDS/LCH
Laurie Wakschlag, PhD
Developmental Psychologist, MSS/FSM
BASIC SCIENCE
Characterizing Dynamic Epigenomic CVH Markers in Early Life
PI: Lifang Hou, MD, PhD
Genetic Epidemiology, DPM/FSM
What are the molecular mechanisms and signals of CVH loss or preservation in early life?
Elizabeth Norton, PhD
Developmental Cognitive Neuroscientist, CSD/SOC