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Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms  Sarah J. Van Vickle-Chavez,

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Presentation on theme: "Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms  Sarah J. Van Vickle-Chavez,"— Presentation transcript:

1 Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms  Sarah J. Van Vickle-Chavez, BA, William S. Tung, MD, Tarek S. Absi, MD, Terri L. Ennis, BS, Dongli Mao, MD, J. Perren Cobb, MD, Robert W. Thompson, MD  Journal of Vascular Surgery  Volume 43, Issue 5, Pages (May 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Aortic dilatation and structural changes during the development of elastase-induced abdominal aortic aneurysms (AAAs). A, Percentage of aortic dilatation at various intervals after perfusion with elastase or heat-inactivated elastase (controls). Data shown reflect the mean ± SE. The threshold for definition of AAAs is indicated by the horizontal line. *P < .001, elastase vs controls, Mann-Whitney test. B, Representative sections of mouse aortic tissue obtained at various intervals after perfusion with elastase or heat-inactivated elastase (controls) (stain, Verhoeff–van Gieson; original magnification, ×40). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Temporal expression profiles for selected cytokines, chemokines, adhesion molecules, and cellular receptors. Relative patterns of expression after aortic perfusion with elastase vs heat-inactivated elastase controls are shown for selected genes. (A) Interleukin 6 (gene ID 16193), (B) interleukin 1β (gene ID 16176), (C) monocyte chemotactic protein (MCP)-3 (gene ID 20306), (D) MIP-1α (gene ID 20302), (E) MIP-1β (gene ID 20303), (F) MIP-2 (gene ID 20310), (G) MIG (gene ID 17329), (H) vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) (gene ID 22339), (I) CD14/lipopolysaccharide (LPS) receptor (gene ID 12475), (J) ICAM-1 (gene ID 15894), (K) platelet endothelial cell adhesion molecule (PECAM)-1/CD31 (gene ID 18613), (L) integrin β1 (gene ID 16412), (M) integrin αM (gene ID 16409), (N) endothelial ligand for l-selectin (glycam 1; gene ID 14663), (O) myeloid cell leukemia differentiation antigen (gene ID 17210), (P) interleukin 1 receptor (gene ID 16177), (Q) interleukin 2 receptor γ (gene ID 16186), and (R) urokinase receptor (uPAR; gene ID 18793). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Temporal expression profiles for selected proteinases, protease inhibitors, extracellular matrix proteins, and proteins involved in cellular metabolism, stress response, and growth/apoptosis. Relative patterns of expression after aortic perfusion with elastase vs heat-inactivated elastase controls are shown for selected genes. (A) Gelatinase A/matrix metalloproteinase (MMP)-2 (gene ID 17390), (B) gelatinase B/MMP-9 (gene ID 17395), (C) dipeptidyl peptidase I (cathepsin C; gene ID 13032), (D) interleukin-converting enzyme (ICE; gene ID 12362), (E) TIMP-3 (gene ID 21859), (F) cystatin C (gene ID 13010), (G) protease nexin I (gene ID 20720), (H) osteopontin (gene ID 20750), (I) thrombospondin 1 (gene ID 21825), (J) fibrillin 1 (gene ID 14118), (K) decorin (gene ID 13179), (L) laminin B2 (gene ID ), (M) cyclin E2 (gene ID 12448), (N) hypoxia-inducible factor (HIF)-1α (gene ID 15251), (O) heat shock protein 84 (gene ID 15516), (P) glutathione-S-transferase 5 (GST-5; gene ID 14863), (Q) apolipoprotein E (gene ID 11816), and (R) vimentin (gene ID 22352). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

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