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Tissue Factor Pathway Inhibitor Ixolaris Improves Disease Outcome in Progressive SIVsab-infected Pigtail Macaques Tianyu He Non-pathogenic Pathogenic Pandrea.

Published byBirgit Geisler Modified over 5 years ago

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Presentation on theme: "Tissue Factor Pathway Inhibitor Ixolaris Improves Disease Outcome in Progressive SIVsab-infected Pigtail Macaques Tianyu He Non-pathogenic Pathogenic Pandrea."— Presentation transcript:

1 Tissue Factor Pathway Inhibitor Ixolaris Improves Disease Outcome in Progressive SIVsab-infected Pigtail Macaques Tianyu He Non-pathogenic Pathogenic Pandrea I, et al. Blood. 2012

2 Tissue factor (TF) expression increases in chronic SIV infection.
Funderburg NT, et al. Blood. 2010 Tissue factor (TF) expression increases in chronic SIV infection. TF expression increases not only in blood, but also in mucosal tissue.

3 In vitro specificity of Ixolaris
In vivo efficacy of Ixolaris Conclusion: TF bridges hypercoagulation and IA/INFL during chronic SIV infection. Blocking TF with Ixolaris improves clinical outcome of progressive SIV infection.

4 Conclusion Chronic HIV/SIV Infection
Immune activation and inflammation Comorbidities Hypercoagulation

5 Acknowledgement Funding Apetrei/Pandrea lab NIH University of Vermont
George Haret-Richter Tammy Dunsmore Benjamin Policicchio Kevin Raehtz Egidio Brocca-Cofano Cuiling Xu NIH Bruno Andrade Ivo Francischetti Dongying Ma Irini Sereti Melissa Schechter University of Vermont Russel Tracy Universidade de Lisboa Ruy Ribeiro Funding Intramural Research Program, NIAID; Bench-to-Bedside award R01HL S1; R01 HL123096; R01 HL117715; R01 AI119346; R01AI104373

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