Presentation is loading. Please wait.

Presentation is loading. Please wait.

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,

Published byThiago Galvão Brás Modified over 6 years ago

Similar presentations

Presentation on theme: "Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,"— Presentation transcript:

1 Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts 
Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD, Susanne Lau, MD, PhD, Thomas Keil, MD, MScPH, Ulrich Wahn, MD, Oliver Fuchs, MD, PhD, Petra Ina Pfefferle, PhD, DrPH, Elisabeth Schmaußer-Hechfellner, BSc, Jon Genuneit, MD, Roger Lauener, MD, Anne M. Karvonen, PhD, Caroline Roduit, MD, Jean-Charles Dalphin, MD, PhD, Josef Riedler, MD, Juha Pekkanen, MD, PhD, Erika von Mutius, MD, Markus J. Ege, MD Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L. Bergmann, Karl E. Bergmann, Andreas Reich, Linus Grabenhenrich Bianca Schaub, Georg J. Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun-Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD, Susanne Lau, MD, PhD, Thomas Keil, MD, MScPH, Ulrich Wahn, MD, Oliver Fuchs, MD, PhD, Petra Ina Pfefferle, PhD, DrPH, Elisabeth Schmaußer- Hechfellner, BSc, Jon Genuneit, MD, Roger Lauener, MD, Anne M. Karvonen, PhD, Caroline Roduit, MD, Jean-Charles Dalphin, MD, PhD, Josef Riedler, MD, Juha Pekkanen, MD, PhD, Erika von Mutius, MD, Markus J. Ege, MD Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L. Bergmann, Karl E. Bergmann, Andreas Reich, Linus Grabenhenrich Bianca Schaub, Georg J. Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun- Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD, Susanne Lau, MD, PhD, Thomas Keil, MD, MScPH, Ulrich Wahn, MD, Oliver Fuchs, MD, PhD, Petra Ina Pfefferle, PhD, DrPH, Elisabeth Schmaußer-Hechfellner, BSc, Jon Genuneit, MD, Roger Lauener, MD, Anne M. Karvonen, PhD, Caroline Roduit, MD, Jean-Charles Dalphin, MD, PhD, Josef Riedler, MD, Juha Pekkanen, MD, PhD, Erika von Mutius, MD, Markus J. Ege, MD Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L. Bergmann, Karl E. Bergmann, Andreas Reich, Linus Grabenhenrich Bianca Schaub, Georg J. Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun-Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey  Journal of Allergy and Clinical Immunology  Volume 139, Issue 6, Pages e12 (June 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Journal of Allergy and Clinical Immunology 2017 139, 1935-1945
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 A and B, Selection of study populations.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 2 LCs of atopy as characterized by allergen specificity, time course, and sIgE levels. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 3 Associations of asthma-related conditions with LCs and classical definitions of atopic sensitization at age 6 years. *Because there was no case of lifetime asthma in this LC, we calculated a conservative estimation of the odds ratio (OR) based on one case of asthma in this LC, which was simulated at random. Black point estimates with error bars mark the LCs as reference, red marks the classical definitions as a comparison. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 4 Atopy phenotypes in relation to the distribution of LCs in both populations. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 5 Absolute sIgE levels (A) and ratio of IL-5 to IFN-γ expression (B) at age 6 years. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig 6 Path diagram comparing severe atopy with the other atopy phenotypes, including its features, lung function, and asthma in both populations. Excessive sIgE production is defined as incremental increase of seasonal sIgE production during the first 6 years. High sIgE levels are determined at age 6 years. Significant associations are shown by solid arrows. Absent associations are represented by interrupted dotted arrows. Values represent association estimates from the final model, including significant paths only. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig 7 Proportion of nonasthmatic children with reduced lung function by LCs. Reduced lung function was defined as values in the lowest decile of the FEV1 distribution. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Fig E1 Distribution of LCs across study centers.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

11 Fig E2 Prediction of LCs by classical definitions of sensitization at age 6 years. Dots mark the sensitization status (from right to left: unsensitized and CAP classes 1-3). Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

12 Fig E3 Associations of health conditions with LCs and classical definitions of atopic sensitization at age 6 years. *Because there was no case of late-onset wheeze in this LC, we calculated a conservative estimation of the OR based on 1 case of late-onset wheeze in this LC, which was simulated at random. Black point estimates with error bars mark the LCs as reference, and red marks the classical definitions as comparison. Late-onset wheeze was defined as described by Depner et al.3 Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

13 Fig E4 Associations of LCs with parental atopy.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

14 Fig E5 Sensitivity analyses omitting single dimensions of LCA.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

15 Fig E6 Comparing disease associations across all sensitivity analyses. *Because there was no case of lifetime asthma in this LC, we calculated a conservative estimation of the odds ratio (OR) based on 1 case of asthma in this LC, which was simulated at random. Black point estimates with error bars mark the LCs as reference, and red marks the classical definitions as a comparison. Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

16 Fig E7 Number of sensitizations to different allergen specificities across LCs (CAP classes 1-3). Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

17 Fig E8 Absolute sIgE levels at age 6 years.
Journal of Allergy and Clinical Immunology  , e12DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts  Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,"

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Infant-onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention.

Infant-onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention.
Early-life determinants of asthma from birth to age 20 years: A German birth cohort study  Linus B. Grabenhenrich, MD, MPH, Hannah Gough, Andreas Reich,

Early-life determinants of asthma from birth to age 20 years: A German birth cohort study  Linus B. Grabenhenrich, MD, MPH, Hannah Gough, Andreas Reich,
Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years  Linus B. Grabenhenrich, MD, MPH, Thomas Keil, MD, MSc, Andreas Reich,

Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years  Linus B. Grabenhenrich, MD, MPH, Thomas Keil, MD, MSc, Andreas Reich,
Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children  Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children  Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.
Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,
Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children  Markus Johannes.

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children  Markus Johannes.
Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk  Tabea Brick, BA, Yvonne Schober, PhD, Christian Böcking, PhD, Juha.

Ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk  Tabea Brick, BA, Yvonne Schober, PhD, Christian Böcking, PhD, Juha.
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion  Anna Lluis, MSc, Michaela Schedel,

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion  Anna Lluis, MSc, Michaela Schedel,
Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis  Remo Frei, PhD, Ruth Ferstl, PhD,

Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis  Remo Frei, PhD, Ruth Ferstl, PhD,
Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study  Georg Loss, MSc, Sondhja Bitter, MD, Johanna Wohlgensinger,

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study  Georg Loss, MSc, Sondhja Bitter, MD, Johanna Wohlgensinger,
Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children  Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children  Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,
Georg Loss, PhD, Martin Depner, PhD, Laurien H. Ulfman, PhD, R. J

Georg Loss, PhD, Martin Depner, PhD, Laurien H. Ulfman, PhD, R. J
Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood  Anna Lluis, PhD, Martin.

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood  Anna Lluis, PhD, Martin.
Markus J. Ege, MD, David P. Strachan, MD, William O. C. M

Markus J. Ege, MD, David P. Strachan, MD, William O. C. M
Atopic sensitization in the first year of life

Atopic sensitization in the first year of life
The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses  Linus Grabenhenrich, MD, MPH, Lars Lange, MD, Magdalena.

The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses  Linus Grabenhenrich, MD, MPH, Lars Lange, MD, Magdalena.

Similar presentations

Ads by Google