3. Setting the Stage – PAH Therapy Trials

4. Current PAH Pharmacotherapies

5. History of LHF Therapy

6. Disease Modification in LHF

7. HFrEF Lessons Learned – Moving Forward in PAH

8. RV Structure and Function in PH – The Downward Spiral

9. Growth and Immune Response Dysregulation in PAH

10. RV Function in PAH

11. Lessons From HFpEF RV-PA and RV-LV Interactions

12. Right Heart and Survival in PAH – REVEAL Registry Data

13. RV-PA and RV-LV Interactions

14. Evolution of End Point-Driven Trials in PAH

16. Current and Future Challenges in End Point Design

17. Right Heart vs Left Heart Therapies

18. Designing PAH Trials – The Next Steps

19. Combination Therapy in PAH

20. Combination Therapy in PAH (cont)

21. Conclusion

22. Abbreviations

23. Abbreviations (cont)

24. References

25. References (cont)

26. References (cont)

27. References (cont)