3. PCSK9 Loss-of-function Mutations

4. PCSK9-Mediated Degradation of LDL-R

5. Evolution of Therapeutic Monoclonal Antibodies

7. Effect of PCSK9 Inhibitors on LDL-C in Heterozygous FH

8. DESCARTES % Change in LDL-C From Baseline at Week 52 in Patients With Hypercholesterolemia

9. GAUSS-1 % Change in LDL-C From Baseline at Week 12 in Statin-Intolerant Patients

10. Effect of PCSK9 Monoclonal Antibodies on ApoB and Lp(a)

11. Role of apoB

12. How Low Is Too Low?

13. PCSK9 CV Outcomes Trials

14. TESLA Trial Evaluating PCSK9 Antibody in Homozygous FH

15. Abbreviations

16. Abbreviations (cont)

17. References

18. References (cont)

19. References (cont)