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Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape

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Presentation on theme: "Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape"— Presentation transcript:

1 Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape
Xia Gao, Jason W. Locasale  Cell Metabolism  Volume 24, Issue 6, Pages (December 2016) DOI: /j.cmet Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 LKB1 Loss Promotes Tumorigenesis through Interlinked Metabolic and Epigenetic Reprogramming In comparison to KRASG12D/+ (K) cells, KRASG12D/+;LKB1−/− (KL) cells were highly glycolytic, with glucose diverted for serine biosynthesis that supports synthesis of S-adenosyl methionine (SAM) and eventually leads to increased DNA methylation, particularly the methylation at retrotransposon elements. Loss of LKB1 leads to elevated DNA methyltransferase (DNMT) activity. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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