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Dry AMD and GA: The Present and Future
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What Is AMD?
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Clinical Features of AMD
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Characteristics of Early AMD
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Characteristics of Intermediate AMD
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Characteristics of Advanced AMD
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Pathophysiology of AMD
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Dry AMD and Atrophy Associated With Increased Lipofuscin/A2E
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Amyloid Found in Dry AMD
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Complement Activation in Dry AMD
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Genetic Correlations Between Complement Cascade and AMD
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Risk Factors for AMD
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Symptoms of AMD
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Diagnosis of AMD
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Benefit of Supplementation in AMD AREDS Study
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Evaluation of Further Supplementation AREDS2 Study
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Current Management in Early AMD
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Current Management of Intermediate AMD
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Current Management of Advanced AMD
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Summary: Dry AMD Treatment in 2016
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Emerging Therapeutic Strategies in Dry AMD
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Visual Cycle Modulation
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Emixustat: Potential Mechanism of Action
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Phase 2b/3 Trial of Emixustat SEATTLE Study
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Anti-Amyloid Antibodies
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Neuroprotection
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Global Inflammation Suppression
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Complement Inhibition C5 and C3 Inhibitors
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Lampalizumab (Anti-Factor D)
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Phase 2 MAHALO Study of Lampalizumab in GA Secondary to AMD
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Efficacy Results From MAHALO Study
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Lampalizumab Phase 3 Trials CHROMA and SPECTRI
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Stem Cell Therapy for Atrophic AMD
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hESC RPE Phase 1/2 Study Surgical Approach
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Concluding Remarks
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Abbreviations
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Abbreviations (cont)
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Abbreviations (cont)
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