4. Poly Ion Complex assemblies-PICs
Objectif : former des associations de polymères par
interactions ioniques plutôt que par effet hydrophobe + or
Double-hydrophilic block copolymer
with one charged block
Transport de molécules
Formation de matériaux
Polyelectrolyte
Mn+

5. Poly Ion Complex assemblies-PICs
PEO -PAA
DGL

6. Poly Ion Complex assemblies-PICs
H2PO4-
100nm
100nm
D ̴ 22-27  nm

7. Polymer based Nanocarriers
Dh (nm)
 (mV)
PEO(2000)-PCL(2800) 20
-10
PEO(5000)-PCL(4000) 25
PEO (5000)-PCL (11000)
165.8 -
PEO(2400)-PDLLA(2000) 30
-2.4
PEO(3100)-PS(2300)
-1.8
PEO(1400) PMMA (5600)
633.8
nanoprecipitation
nanoprecipitation , dialysis
or film rehydration /extrusion

8. Hybrid Nanocarriers GUV Scale bar: 200 nm Scale bar: 10 mm 35 mol %

9. Evaporation or dialysis
Preparation Methods
Cosolvent Method
Film rehydration
Evaporation or dialysis
Solvent
Dissolution
Addition to water
or reverse
Polymer
Photosensitizer
Dissolution
Polymer
Addition of water
Evaporation

10. Variation 5x stronger // literature
Mechanical stress induced by a light-responsive hydrogel
Collaborations : C. Lorenzo (ITAV), C. Galès (I2MC, INSERM)
Résultats : UV
Vis
50% change
30% change
Variation 5x stronger
// literature