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Role of nasal nitric oxide in the resolution of experimental rhinovirus infection  Scherer P Sanders, PhD, David Proud, PhD, Solbert Permutt, MD, Edward.

Published bySudomo Setiabudi Modified over 6 years ago

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Presentation on theme: "Role of nasal nitric oxide in the resolution of experimental rhinovirus infection  Scherer P Sanders, PhD, David Proud, PhD, Solbert Permutt, MD, Edward."— Presentation transcript:

1 Role of nasal nitric oxide in the resolution of experimental rhinovirus infection 
Scherer P Sanders, PhD, David Proud, PhD, Solbert Permutt, MD, Edward S Siekierski, BS, Robin Yachechko, BS, Mark C Liu, MD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 4, Pages (April 2004) DOI: /j.jaci

2 Fig 1 Symptom scores and viral titers for nasal lavage samples: see the “Methods” section (mean±SEM, n=6). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

3 Fig 2 Differential counts performed on cells recovered from nasal lavage fluid: lymph, lymphocytes; mono, monocytes; pmn, neutrophils; eo, eosinophils (mean±SEM, n=6). ∗P<.05. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

4 Fig 3 Comparison of the wall concentration of eNO measured from the lower airways and nose (see the “Methods” section) of subjects during experimental HRV infection. Data expressed as a percentage of the baseline value (mean±SEM, n=6). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

5 Fig 4 A, Standard curve for real-time RT-PCR of NOS2 by using first-strand cDNA standard (mean±SEM, n=3). B, Correlation of nasal NOS2 mRNA and increases in concentration of nasal eNO on day 3 after HRV infection (n=5, insufficient sample in one subject). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

6 Fig 5 Symptom scores on day 4 were inversely correlated with the concentration of nasal eNO (n=6). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

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