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Retinoblastoma Teaches a New Lesson

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1 Retinoblastoma Teaches a New Lesson
Hein te Riele  Cell  Volume 131, Issue 2, Pages (October 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Retinoblastoma Development in Mice
Loss of pocket proteins allows proliferating progenitor cells in the retina to differentiate into outer and inner nuclear layer precursor cells. These cells continue to proliferate at least for a while, but then certain retinal cell types, the rods, cones, ganglion, and bipolar cells die, whereas other retinal cells (amacrine, horizontal, and Müller glia cells) survive but become arrested in the cell cycle. A second event that suppresses the p53 pathway may alleviate cell-cycle arrest leading to proliferation of differentiated cells. Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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