1. Live or Die? Depends on Who You Are
Takaaki Kuwajima, Carol Mason 
Neuron 
Volume 94, Issue 6, Pages (June 2017)
DOI: /j.neuron
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Regulation of RGC survival or death after optic injury
(A) Among the cells in the retina, only RGC axons project to the brain. RPE, retinal pigment epithelium; P, photoreceptor; H, horizontal cell; B, bipolar cell; A, amacrine cell; M, Müller glia. Retinal ganglion cells, (α), α-RGC (orange); (?), unidentified RGC subtypes (fuchsia, dark purple).
(B) After injury, knockdown (KD) of Dlk and Lzk (Dlk + Lzk) or their downstream targets, Sox11, Atf2, Mef2a, and Jun (Sox11 + Atf2 + Mef2a + Jun), rescues RGCs from death. However, which RGC subtypes are maintained is unclear.
(C) Knockout (KO) of PTEN promotes axon regeneration exclusively in α-RGCs (α), which are resistant to cell death even after axotomy (Duan et al., 2015). Overexpression (OE) of Sox11 kills α-RGCs but promotes axon regeneration in other RGC subtypes, whose identity is unknown. The combination of PTEN knockout and Sox11 overexpression enables axons to extend farther in these unidentified RGC subtypes compared with either PTEN knockout or Sox11 overexpression alone.
Neuron  , DOI: ( /j.neuron )
Copyright © 2017 Elsevier Inc. Terms and Conditions