1. iNO Delivery

2. Use in Non-ECMO Centers and Transport
Have system in place to continue iNO during transport even if no apparent response occurs1,2
Use HFOV + iNO with caution, if at all, in non-ECMO centers2
1. Kinsella JP et al. J Pediatr. 2000;136:
2. Kinsella JP et al. Pediatrics. 2002;109:

3. Nitric Oxide Delivery System Characteristics
iNO must be delivered through a system with these characteristics
Operator-determined concentrations of NO
Constant concentration throughout respiratory cycle
Minimal generation of NO2
Precise monitoring of iNO, NO2, and O2 along with alarms
Backup battery supply
Reserve NO delivery system
INOmax® [package insert]. Clinton, NJ: INO Therapeutics, Inc; Revised April 2004.

4. INOvent® Delivery System
Closed-loop system that can be used with most conventional mechanical ventilators1
Safely delivers NO when used with HFOV2
Provides a constant, stable, and accurate concentration of NO1,2
Delivery of NO dose does not fluctuate with ventilatory pattern1
Formation of NO2 is minimal1
Kirmse M et al. Chest. 1998;113:
Fujino Y et al. Respir Care. 2000;45:

5. INOvent® Delivery System

6. Therapeutic Decisions
FDA-approved therapies
INOmax® (nitric oxide) for HRF in neonates
Surfactant for RDS
Tolazoline (no longer available)

7. Therapeutic Decisions
Insufficiently tested therapies
Paralysis
Alkalosis
Bicarbonate infusion
Hyperventilation
Endothelin antagonist and sodium nitroprusside
Surfactant for MAS, pneumonia, PPHN, or CDH