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Destruction of RhoA CULtivates Actin

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Presentation on theme: "Destruction of RhoA CULtivates Actin"— Presentation transcript:

1 Destruction of RhoA CULtivates Actin
Shuangding Wu, Dieter A. Wolf  Molecular Cell  Volume 35, Issue 6, Pages (September 2009) DOI: /j.molcel Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Model of CRL3BACURD-Mediated Destruction of RhoA
Active RhoA-GTP is converted to RhoA-GDP by GAP activity, which may respond to extracellular cues. RhoA-GDP, potentially after additional modification triggered by exogenous stimuli, is then recognized by a dimeric CRL3 complex containing hBACURDs1 and 2 as substrate receptors. Polyubiquitylation leads to proteasomal degradation of RhoA, thus affecting actin dynamics, cell migration, and potentially metastasis. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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