1. Primary Mammary (Non-Hodgkin) Lymphoma Presenting as Locally Advanced Breast Cancer 
Sandhya Pruthi, MD, Vania K. Stafyla, MD, Stephen W. Phillips, MD, Luis F. Porrata, MD, Carol A. Reynolds, MD 
Mayo Clinic Proceedings 
Volume 79, Issue 10, Pages (October 2004)
DOI: /
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2. FIGURE 1
Asymmetrical enlargement of left breast with erythema (left) and peau d'orange (right).
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3. FIGURE 2
Bilateral mammography shows a large, high-density, poorly defined mass in the central and lateral aspects of the left breast. A nodule with benign features is evident in the lower outer quadrant of the right breast. Left, Craniocaudal (CC) view. Right, Mediolateral oblique (MLO) view. L = left; R = right.
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4. FIGURE 3
Malignant lymphoma, diffuse large B-cell type. Left, Tumor cells diffusely infiltrating breast parenchyma (hematoxylin-eosin, original magnification ×50). Right, Diffuse infiltrate is composed of tumor cells with prominent nucleoli and scant cytoplasm (hematoxylineosin, original magnification ×200).
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5. FIGURE 4
Malignant lymphoma, diffuse large B-cell type. Tumor cells show strong reactivity with B-cell marker CD20 (immunohistochemical CD20 stain, original magnification ×200).
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6. FIGURE 5
Postchemotherapy bilateral mammography shows a marked reduction in the size of the left breast mass. Left, Craniocaudal (CC) view. Right, Mediolateral oblique (MLO) view. L = left; R = right.
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