1. Arachidonate Metabolism
Title slide - C20 metabollism

2. Eicosanoid Function Inflammatory response Pain & fever
Regulate blood pressure
Induce blood clotting
Induce labor
Regulate wake/sleep
Six functions of C20-derived compounds

3. Prostaglandin structures.

4. The synthesis of prostaglandin precursors.

5. Recovery of arachidonic acid from membrane phospholipids.

6. The two biosynthetic pathways: cyclic & linear.

7. The cyclic pathway with the site of action of aspirin.

8. The reactions catalyzed by PGH2 synthase with two enzyme activities on the same protein: cyclooxygenase and peroxidase.

9. The X-ray structure of PGH2.

10. NSAID structures.

11. Aspirin acetylates ser 530 and blocks the cyclooxygenase activity.

12. The lipoxygenase-catalyzed oxidation of arachidonate to 5-HPETE.

13. The formation of leukotrienes.