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Figure 3 Metabolism in homeostatic chondrocytes

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Presentation on theme: "Figure 3 Metabolism in homeostatic chondrocytes"— Presentation transcript:

1 Figure 3 Metabolism in homeostatic chondrocytes
Figure 3 | Metabolism in homeostatic chondrocytes. In healthy joints, chondrocytes utilize glucose as well as other metabolic fuels and sources of energy. Glucose utilization via glycolysis and oxidative phosphorylation helps to maintain an optimal level of mitochondrial function and biogenesis. The metabolism of healthy chondrocytes is therefore optimized to maintain normal energy homeostasis via signalling through the AMPK–SIRT1–PGC1α pathway. AMPK, AMP-activated protein kinase; ETC, electron transport chain; GLUT1, glucose transporter type 1; PGC1α, peroxisome proliferator-activated receptor γ co-activator 1α; ROS, reactive oxygen species; SIRT1, NAD-dependent protein deacetylase sirtuin-1; TCA, tricarboxylic acid. Mobasheri, A. et al. (2017) The role of metabolism in the pathogenesis of osteoarthritis Nat. Rev. Rheumatol. doi: /nrrheum

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