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Volume 55, Issue 3, Pages (March 1999)

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Presentation on theme: "Volume 55, Issue 3, Pages (March 1999)"— Presentation transcript:

1 Volume 55, Issue 3, Pages 821-832 (March 1999)
22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure  Marie-Claude Monier-Faugere, Zhaopo Geng, Robert M. Friedler, Quanle Qi, Noboru Kubodera, Eduardo Slatopolsky, Hartmut H. Malluche  Kidney International  Volume 55, Issue 3, Pages (March 1999) DOI: /j x Copyright © 1999 International Society of Nephrology Terms and Conditions

2 Figure 1 Changes in serum creatinine levels in nephrectomized (Nx) or sham-operated animals (Sham) receiving 22-oxacalcitriol (OCT) or vehicle (Veh) during Phase 1 of the study. Nx + OCT (▪); Nx + Veh (□); Sham + OCT (•); Sham + Veh (○). Surgery (Nx or Sham) was done at time -20 weeks, OCT or Veh treatment started at time 0. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

3 Figure 2 Changes in serum parathyroid hormone (•) and serum calcium (○) levels in nephrectomized (Nx) animals receiving 22-oxacalcitriol (OCT) for more than 50% of the time (Nx + OCT> 50%, less than 50% of the time (Nx + OCT < 50%), or vehicle (Veh) during phase 1 of the study. Surgery (Nx or Sham) was done at time -20 weeks. OCT or Veh treatment started at time 0. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

4 Figure 3 Changes in serum phosphorus levels in nephrectomized (Nx) or sham-operated animals (Sham) receiving 22-oxacalcitriol (OCT) or vehicle (Veh) during phase 1 of the study. Symbols are: (▪) Nx + OCT; (□) Nx + Veh; (•) Sham + OCT; (○) Sham + Veh. Surgery (Nx or Sham) was done at time -20 weeks, OCT or Veh treatment started at time 0. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

5 Figure 4 Changes in serum parathyroid hormone levels in nephrectomized (Nx) or sham-operated animals (Sham) receiving 22-oxacalcitriol (OCT) or vehicle (Veh) after crossover. Symbols are: (▪) Nx + OCT; (□) Nx + Veh; (•) Sham + OCT; (○) Sham + Veh. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

6 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

7 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

8 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

9 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

10 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

11 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

12 Kidney International 1999 55, 821-832DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions


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