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H. pylori GPS: Modulating Host Metabolites for Location Sensing

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1 H. pylori GPS: Modulating Host Metabolites for Location Sensing
Daniela Keilberg, Karen M. Ottemann  Cell Host & Microbe  Volume 18, Issue 2, Pages (August 2015) DOI: /j.chom Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Bacteria Can Sense Host Metabolites as Chemotaxis Ligands
Host cells produce a wide range of metabolites that can be sensed by colonizing bacteria. Helicobacter pylori uses a mechanism to hydrolyze urea to CO2 and NH3. This reaction both helps to buffer the bacterium from harsh stomach acid and also lowers the amount of urea to a range that allows a chemotaxis response Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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