1. Novel Design of Vascular Clamp to Minimize Vessel Injury
Neha Patel, Nadia Hussein, Eric Walk, Max Hammond, Francis Simpson

2. Surgeon holding clamp (non-dominant hand)
Problem Statement
Complaint about damage caused by arterial clamps to vessels
Complaint about requirement to use non-dominant hand to operate the device, too much training required
Surgeon holding clamp (non-dominant hand)

3. Area where vessel damage can be seen
Performance Criteria
Training Time
Device Mass
Vessel Damage
Occlusion of Flow
Sterility
Cost
Profitability
Area where vessel damage can be seen

4. Sample carotid endarterectomy surgery
Primary Objective
Arterial clamps are used to prevent excessive bleeding in surgery
50 years of stagnant progress in design of arterial clamps
Current clamps
Create endothelial and smooth muscle damage in vessels
Hard to use
Goal is to reduce muscular damage and reduce training time
Sample carotid endarterectomy surgery

5. Visualizing the Problem

7. Solution Description: Pieces of Clamp

8. Solution Description: Assembled Clamp

9. Goals Training Time – reduce by 50% Device Mass – maintain or reduce
Vessel Damage – reduce by at least 20%
Occlusion of Flow – maintain 100% occlusion for 36 hours
Sterility – ensure that all parts can be sterilized or are disposable
Cost – Less than $2000 per clamp
Profitability – Ensure that product can be made without loss

10. Factors Material Number of Disposable Parts Sterilization method
Metal
Plastics
Number of Disposable Parts
Sterilization method
Handle Design
Closure Method
IV tubing
Autoclave

11. System and Environment
Used in OR
Held in non-dominant hand of the surgeon
Placed around the patient’s artery and inflated

12. Experiment Block Diagram
This testing will be completed by the Brophy Lab.
Occlude Resected Vessel with New Clamp for 5-10 hours
Assess Damage to the Endothelium and Muscular Tissues
Compare to Existing Data
Determine Relative Vascular Damage Level
Have Surgical Resident(s), with no previous exposure to the new design, Use Clamp in animal surgery
Assess ease of use with questionnaire of Surgical Resident(s)
Compare to questionnaire data for existing clamps
Determine Relative Ease of Use Level
Need to show examples of damaged and non-damaged vessels, what is damage?

13. Testing Methods Radnoti Glass Technology force transducer
Powerlab data acquisition system and Chart software
Depolarized using KCl
Confirmed viability via KCl bath
Unmanipulated PCA
Control
clamped with a debakey clamp
clamped with a hydrogrip. Rings were then tested for endothelial-dependent relaxation.

14. Testing Methods

15. Testing Methods

16. Testing Methods
Clamped period
Force (g)

17. Current Status Prototype
Awaiting 2nd run on prototype, 1st was not made correctly
Will assemble rubber parts by hand, have acquired appropriate adhesives.

18. Upcoming Tasks Creating Rubber Parts Testing
Planning for Poster Session

19. Performance

20. Conclusions

21. Informal Observations

22. Recommendations