Presentation is loading. Please wait.

Presentation is loading. Please wait.

Bone Morphogenetic Proteins

Published byTheresa Schmitt Modified over 6 years ago

Similar presentations

Presentation on theme: "Bone Morphogenetic Proteins"— Presentation transcript:

1 Bone Morphogenetic Proteins
11/16/2018 Bone Morphogenetic Proteins Signal Sequence N Pro-domain Mature Domain C Proteolytic cleavage C C Folding & dimerization C Active BMP dimer BMP: bone morphogenetic protein (osteogenin) C: cysteine Eric Niederhoffer SIU-SOM

2 BMP Signaling Pathways
11/16/2018 BMP Signaling Pathways C C C GS box Smad pathway MAPK pathway (s) Type II receptor Type I receptor BMP: bone morphogenetic protein (osteogenin) GS box: glycine-serine protein motif MAPK: mitogen-activated protein kinase (mitogen = mitosis-stimulating growth factors) Smad: Caenorhabditis elegans “Sma” mothers against decapentaplegic Target gene

Download ppt "Bone Morphogenetic Proteins"

Similar presentations

SIGNALING FROM THE CELL SURFACE TO THE NUCLEUS

SIGNALING FROM THE CELL SURFACE TO THE NUCLEUS
Cell signaling Lecture 8. Transforming growth factor (TGF β) Receptors/Smad pathway BMP7 TGF β1, TGF β2, TGF β3 Dpp Inhibins Activins TGF β receptors.

Cell signaling Lecture 8. Transforming growth factor (TGF β) Receptors/Smad pathway BMP7 TGF β1, TGF β2, TGF β3 Dpp Inhibins Activins TGF β receptors.
Cell Communication-II (Fall 2010) Pin Ling ( 凌 斌 ), Ph.D. Department of Microbiology & Immunology, NCKU ext 5632; Reference: “Mechanisms.

Cell Communication-II (Fall 2010) Pin Ling ( 凌 斌 ), Ph.D. Department of Microbiology & Immunology, NCKU ext 5632; Reference: “Mechanisms.
CHMI 4237 E Special topics in Biochemistry Eric R. Gauthier, Ph.D. Dept. Chemistry-Biochemistry Laurentian University Cell proliferation 4- Signaling to.

CHMI 4237 E Special topics in Biochemistry Eric R. Gauthier, Ph.D. Dept. Chemistry-Biochemistry Laurentian University Cell proliferation 4- Signaling to.
Chapter 15- Cell Communication Part I- General signaling strategies

Chapter 15- Cell Communication Part I- General signaling strategies
Signal transduction. General scheme There are two general types of receptors: cell-surface and intracellular receptors.

Signal transduction. General scheme There are two general types of receptors: cell-surface and intracellular receptors.
Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.
Figure 1 Simplified scheme of TGFβ signalling

Figure 1 Simplified scheme of TGFβ signalling
Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP  CHEST 

Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP  CHEST 
Figure 1. Resistance mechanism against first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). (A) Mutations in the EGFR.

Figure 1. Resistance mechanism against first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). (A) Mutations in the EGFR.
Eric Niederhoffer SIU-SOM

Eric Niederhoffer SIU-SOM
Copyright © 2015 by the American Osteopathic Association.

Copyright © 2015 by the American Osteopathic Association.
Neurotransmitter Storage and Release

Neurotransmitter Storage and Release
OVERVIEW: Signals for cell surface receptors (hydrophilic):

OVERVIEW: Signals for cell surface receptors (hydrophilic):
The Role of SMAD4 (DPC4) in Cancer

The Role of SMAD4 (DPC4) in Cancer
SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.

SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.
John W. Bloom, MD  Journal of Allergy and Clinical Immunology 

John W. Bloom, MD  Journal of Allergy and Clinical Immunology 
Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.
Figure 1 Phylogenetic analysis of BMP superfamily molecules

Figure 1 Phylogenetic analysis of BMP superfamily molecules
Mark D. Kleven, Caroline A. Enns, An-Sheng Zhang  Gastroenterology 

Mark D. Kleven, Caroline A. Enns, An-Sheng Zhang  Gastroenterology 

Similar presentations

Ads by Google