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C. Sanchez, A. -C. Bay-Jensen, T. Pap, M. Dvir-Ginzberg, H

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Presentation on theme: "C. Sanchez, A. -C. Bay-Jensen, T. Pap, M. Dvir-Ginzberg, H"— Presentation transcript:

1 Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis 
C. Sanchez, A.-C. Bay-Jensen, T. Pap, M. Dvir-Ginzberg, H. Quasnichka, R. Barrett-Jolley, A. Mobasheri, Y. Henrotin  Osteoarthritis and Cartilage  Volume 25, Issue 8, Pages (August 2017) DOI: /j.joca Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Schematic representation of the chondrocyte secretome, based on data from mass-spectrometry based proteomic studies. ADAMTS: A Disintegrin And Metalloproteinase with Thrombospondin Motifs, Apo: apolipoprotein, BMP: Bone morphogenetic protein, CCL: Chemokine ligand, CHAD: Chondroadherin, ChM: chondromodulin, CILP: Cartilage intermediate layer protein, CHI3L1: Chitinase-3-like protein 1, COMP: Cartilage oligomeric matrix protein, CRLF: Cytokine receptor-like factor, CRTAC: Cartilage acidic protein, CSF: Macrophage colony-stimulating factor, CTGF: Connective tissue growth factor, Cx: connexin, CXCL: C-X-C motif chemokine ligand, ECM: extracellular matrix protein, ENPP: Ectonucleotide pyrophosphatase/phosphodiesterase family member, EMI: emilin, HSPA5: 78 kDa glucose-regulated protein, HTRA: High-temperature requirement A serine peptidase, IL: Interleukin, LTBP: Latent-transforming growth factor beta-binding protein, MGP: matrix gla protein, MMP: matrix metalloproteinase, PCOLCE: Procollagen C-endopeptidase enhancer, PLOD: Procollagen-lysine,2-oxoglutarate 5-dioxygenase, PRELP: proline-arginine-rich end leucine-rich repeat protein, SERPIN: serine protease inhibitors, SOD: superoxide dismutase, SPARC: Secreted protein acidic and rich in cysteine, TGFBI: Transforming growth factor-beta-induced protein ig-h3, TGF: transforming growth factor, TIMP: tissue inhibitor of metalloproteinase, TNAP: tissue non-specific alkaline phosphatase, TSP: thrombospondin. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions


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