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Victor F. Tapson, MD, David M. Platt, MD, Fang Xia, PhD, Simon A

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1 Monitoring for Pulmonary Hypertension Following Pulmonary Embolism: The INFORM Study 
Victor F. Tapson, MD, David M. Platt, MD, Fang Xia, PhD, Simon A. Teal, BSc, Margarita de la Orden, MSc, Christine H. Divers, PhD, Carol A. Satler, MD, PhD, Vijay N. Joish, PhD, Richard N. Channick, MD  The American Journal of Medicine  Volume 129, Issue 9, Pages e2 (September 2016) DOI: /j.amjmed Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Stepwise process for the diagnosis of chronic thromboembolic pulmonary hypertension. CTA = computed tomographic angiography; CTEPH = chronic thromboembolic pulmonary embolism; MRA = magnetic resonance angiogram. Reproduced with permission; Kim et al.24 The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

3 Figure 2 Selection of patients with incident pulmonary embolism between July 1, 2010 and September 30, ICD-9-CM = International Classification of Disease, Ninth Revision, Clinical Modification; PE = pulmonary embolism. The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

4 Figure 3 Disease monitoring in the 2-year period following the incident pulmonary embolism event. CTA = computed tomographic angiography; ECHO = echocardiogram; ICD-9-CM = International Classification of Disease, Ninth Revision, Clinical Modification; PAG = pulmonary angiography; PH = pulmonary hypertension; RHC = right heart catheterization; VQ = ventilation/perfusion scan. *The 10 prespecified PH symptoms (with ICD-9-CM codes in parenthesis) include syncope (780.2), malaise and fatigue (780.7), dyspnea (786.0), hemoptysis (786.3), chest pain (786.5), dizziness/ vertigo (780.4), gait abnormality (781.2), cardiomegaly (429.3), ascites (789.3), and peripheral edema (782.3). The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

5 Figure 4 Disease monitoring post index pulmonary embolism in patients with a diagnosis of pulmonary hypertension on or after index event. n = 538 patients with a diagnosis of pulmonary hypertension (ICD-9-CM codes or 416.8). CTA = computed tomographic angiography; ECHO = echocardiogram; ICD-9-CM = International Classification of Disease, Ninth Revision, Clinical Modification; PAG = pulmonary angiography; RHC = right heart catheterization; VQ = ventilation perfusion. The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions


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