1. Representative hematoxylin-eosin stained (HE) sections demonstrating immune checkpoint inhibition-related colitis representative HE sections demonstrating immune checkpoint inhibition-related colitis characterised by increased lamina propria cellularity (A, B and D).
Representative hematoxylin-eosin stained (HE) sections demonstrating immune checkpoint inhibition-related colitis representative HE sections demonstrating immune checkpoint inhibition-related colitis characterised by increased lamina propria cellularity (A, B and D). (A) extension of the infiltrate into the submucosa. (B) neutrophilic inflammation with a crypt abscesses, mild cryptitis, mucin depletion of epithelial cells and small foci with minimal increase in intraepithelial lymphocytes. (C) Apoptotic cells in crypt epithelium. (D) Prominent intraepithelial lymphocytosis.
Marnix H Geukes Foppen et al. ESMO Open 2018;3:e000278
Copyright © European Society for Medical Oncology. All rights reserved.