1. Announcements as of 3 December 2008
Last Week of Class & Lab
Renal physiology lectures
GI Physiology lecture
Urinalysis lab
Sign up for Exam Day
Moeller’s section Monday 9am
Davis’s section Friday 9am
Notify & commit no later than Friday of this week!
Exam Week
Take exam on Monday or Friday
Revised Abstracts due no later than 9:00 Friday
Optional (but highly recommended) Meet with professor during exam week for feedback before revising abstract.

2. Figure 14.27
Apply this information to each of the three Test Beverages used in the Urinalysis Lab!

3. Figure 14.30
Apply this information to each of the three Test Beverages used in the Urinalysis Lab!
Cell in the adrenal cortex that respond to AII are also receptors for plasma K+ concentration.
Sodium reabsorption and potassium secretion are coupled.

4. Under hormonal control by Aldosterone!
Figure 14.14
Under hormonal control by Aldosterone!
Sodium reabsorption and potassium secretion are coupled.

5. Lung-kidney connection
Acid-Base Balance

6. Normally, all filtered bicarbonate is “reabsorbed”
Figure 14.31
Normally, all filtered bicarbonate is “reabsorbed”

7. This process is increased during metabolic acidosis
Figure 14.32
This process is increased during metabolic acidosis
Excess H+ eliminated in urine bound to phosphate buffer.

8. This process is increased during metabolic acidosis
Figure 14.33
Filtration
Reabsorption
Secretion
Metabolism
Metabolism of glutamine in tubular cells generate bicarbonate buffer.
This process is increased during metabolic acidosis

9. Father-in-law with emphysema (respiratory case studies lab)
PaCO2 =30 mmHg, plasma pH = 7.47
Hyperventilating: ventilation in excess of metabolism to compensate for loss of alveolar surface area for diffusion of O2
Commensurate loss of CO2
RESPIRATORY ALKALOSIS
Renal compensation……… retain H+ and eliminate HCO3-
Review 3 previous slides.

10. For exam: understand the ventilatory compensation for
Table 14.08
For exam: understand the ventilatory compensation for
Metabolic acidosis as a result of diarrhea and
Metabolic alkalosis as a result of vomiting.

11. Table 14.07

12. Table 14.06